Abstract: We discuss the generation of small neutrino masses from effective operators higher than dimension five, which open new possibilities for low scale see-saw mechanisms. In order to forbid the radiative generation of neutrino mass by lower dimensional operators, extra fields are required, which are charged under a new symmetry. We discuss this mechanism in the framework of a two Higgs doublet model. We demonstrate that the tree level generation of neutrino mass from higher dimensional operators often leads to inverse see-saw scenarios in which small lepton number violating terms are naturally suppressed by the new physics scale. Furthermore, we systematically discuss tree level generalizations of the standard see-saw scenarios from higher dimensional operators.